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ICONS

INNOVATIVE POLYMER COATED CERIUM OXIDE NANOPARTICLES FOR STROKE TREATMENT

Project-ANR-15-CE18-0024 > | N° ANR-15-CE18-0024

February 2016 – August 2019

Stroke is the primary cause of acquired disability and the third highest cause of mortality in developed countries. Its incidence is expected to increase due to the growth of ageing populations. Ischemic stroke, whic represents 80% of all stroke cases, is due to occlusion of a cerebral vessel by a clot, that induces neuronal loss and neurologic deficit. It also induces vascular damage leading to intracerebral haemorrhage, a major stroke complication.

ICONS

INNOVATIVE POLYMER COATED CERIUM OXIDE NANOPARTICLES FOR STROKE TREATMENT

Project-ANR-15-CE18-0024 > | N° ANR-15-CE18-0024

February 2016 – August 2019

Stroke is the primary cause of acquired disability and the third highest cause of mortality in developed countries. Its incidence is expected to increase due to the growth of ageing populations. Ischemic stroke, whic represents 80% of all stroke cases, is due to occlusion of a cerebral vessel by a clot, that induces neuronal loss and neurologic deficit. It also induces vascular damage leading to intracerebral haemorrhage, a major stroke complication.

Pathophysiology of stroke involves many mechanisms including oxidative stress that refers to imbalance between the production of radical oxygen species (ROS, e.g. superoxide anion, hydrogen peroxide and peroxynitrite) and endogenous antioxidant systems. ROS are deleterious both for neurons and vessels but also trigger inflammation, another detrimental phenomenon in stroke, that leads to further oxidative stress. Cerium oxide nanoparticles (CNP) have antioxidant properties, reversibly binding oxygen and shifting between the Ce3+ (reduced) and Ce4+ (oxidized) forms at the particle surface. The objective of the ICONS project was to evaluate the potential of innovative antioxidant CNP as therapeutic agents in stroke.

Polymer in medical field at SPECIFIC POLYMERS

Multi-functional polymer coatings

Within this project, SPECIFIC POLYMERS worked on the synthesis of various biocompatible (co)polymers combining both phosphonic acid moieties and PEGylated chains for the encapsulation of cerium oxide nanoparticles. Indeed, to reach an optimal efficiency, such nanoparticles should be coated to improve their biocompatibility, increase their cellular uptake, enhance their circulation or prevent their clearing through the kidneys. Coating might also be functionalized on their surface with specific moieties to enable the grafting of targeting molecules such as peptides, antibodies or oligoanilines. The synthesis of various multi-functional polymers for encapsulating nanoparticles and conferring on them the appropriate set of above-mentioned properties was achieved during the ICONS project. The common points of all developed polymers are the association of (i) polyethylene glycol chains known to provide exceptional stability, low cellular uptake, biocompatibility and stealth properties with (ii) phosphonic acid anchoring groups that offer high binding affinity towards metallic atoms. We also focused on the association of both the previously mentioned functionality with a third functional group enabling the grafting of different peptides and offering the prospect of stroke treatment and the diagnosis of brain tumors.

Learn even more about ICONS

Related R&D products from our portfolio

Poly(ethylene glycol), α-methoxy,
ω-phosphonic acid

Poly(ethylene glycol), α-ammonium
chloride, ω-phosphonic acid

Poly(PEGMA-stat-
MAPC1 Acid)

Our partners in ICONS project