02 Feb Synthesis and Self-Assembly of UV-Cross-Linkable Amphiphilic Polyoxazoline Block Copolymers: Importance of Multitechnique Characterization Back to Sci. Publications

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AUTHORS

K. Belkhir, O. Cerlati, D. Heaugwane, A. Tosi, B. Tarek Benkhaled, P-L. Brient, C. Chatard, A. Graillot, S. Catrouillet, S. Balor, D. Goudounèche, B. Payré, Pascale Laborie, J-H. Lim, J-L. Putaux, P. Vicendo, L. Gibot, B. Lonetti, A-F. Mingotaud, V. Lapinte

JOURNAL

Langmuir, 38, 51, 16144–16155

DATE

14th February 2023

PRODUCTS

SP-43-0-011 >

SP-4P-0-014 >

ABSTRACT

In the nanomedicine field, there is a need to widen the availability of nanovectors to compensate for the increasingly reported side effects of poly(ethene glycol). Nanovectors enabling cross-linking can further optimize drug delivery. Cross-linkable polyoxazolines are therefore relevant candidates to address these two points. Here we present the synthesis of coumarin-functionalized poly(2-alkyl-2-oxazoline) block copolymers, namely, poly(2-methyl-2-oxazoline)-block-poly(2-phenyl-2-oxazoline) and poly(2-methyl-2-oxazoline)-block-poly(2-butyl-2-oxazoline). The hydrophilic ratio and molecular weights were varied in order to obtain a range of possible behaviors. Their self-assembly after nanoprecipitation or film rehydration was examined. The resulting nano-objects were fully characterized by transmission electron microscopy (TEM), cryo-TEM, multiple-angle dynamic and static light scattering. In most cases, the formation of polymer micelles was observed, as well as, in some cases, aggregates, which made characterization more difficult. Cross-linking was performed under UV illumination in the presence of a coumarin-bearing cross-linker based on polymethacrylate derivatives. Addition of the photo-cross-linker and cross-linking resulted in better-defined objects with improved stability in most cases.